Breakthroughs in cell-polymer binding

 

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1) Polymers with binding groups at the chain ends, unlike similar materials with binding groups along the chain, remain bound to cellular targets even above the LCST when the polymer is in a tightly packed globular state.

 

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2) Binding of end groups of highly branched polymers can progress a water soluble polymer through a coil-to-globule transition.

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3) Cells do not adhere to the open coil state of a highly branched polymer even if the end groups can bind to their cellular targets.