Controlling Cell Adhesion

Depending on their application it can be desirable for polymers to have strong adhesion to cell networks, for example a scaffold to promote regrowth and repair in a wound. Alternatively restricting protein adsorption can be an important role if drug delivery systems wish not to interact with the bodies natural immune system. We utilise a range of different methods to control cell and other biological adhesion.

Important Publications

    1. Production and performance of biomaterials containing RGD-peptides” L. Perlin, S. MacNeil, S. Rimmer, Soft Matter, 4, 2331 (2008)
    2. Cell adhesive hydrogels synthesized by copolymerization of arg-protected Gly-Arg-Gly-Asp-Ser methacrylate monomers and enzymatic deprotection” L. Perlin, S. MacNeil, S.Rimmer Chem Comm 5951 (2008)
    3. Synthesis and properties of amphiphilic networks 3: Preparation and characterization of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate))” S. Rimmer, M.J. German, J. Maughan, Y. Sun, N. Fullwood, J. Ebdon, S. MacNeil, Biomaterials, 26 2219 (2005)
    4. Culture of dermal fibroblasts and protein adsorption on block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate))” Y. Sun , J. Collett , N.J. Fullwood , S. Mac Neil, S. Rimmer, Biomaterials 28 661 (2007)
    5. Synthesis and properties of amphiphilic networks 2: A Differential scanning calorimetric study of poly(dodecyl methacrylate-stat-2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate) networks and adhesion and spreading of dermal fibroblasts on these materials” R. Haigh, N. Fullwood, S. Rimmer, Biomaterials 23 3509 (2002)
    6. Epithelialization of hydrogels achieved by amine surface modification and co-culture with stromal cells” S. Rimmer, C. Johnson, B. Zhao, J. Collier, L. Gilmore, S. Sabnis, P. Wyman, C. Sammon, N.J. Fullwood, S. MacNeil Biomaterials, 28 5319 (2007)
    7. Cytocompatibility of poly(1,2 propandiol methacrylate) copolymer hydrogels and conetworks with or without alkyl amine functionality” S. Rimmer, Stacy-Paul Wilshaw, P. Pickavance, E. Ingham Biomaterials 30 2468 (2009)
    8. R. Plenderleith, C J Pateman, C Rodenburg, John Haycock, Frederik Claeyssens, Chris Sammon and Stephen Rimmer, Soft Matter, 2015 – Hydrogels were patterned with out highly branched polymer particles designed to adhere to fibroblast cells to support tissue regeneration and cell culturing.
    9. Kayleigh Cox-Nowak, Ohood Al-Yamani, Colin A. Grant, Nicola H. Green & Stephen Rimmer, International Journal of Polymeric Materials and Polymeric Biomaterials, 2017
    10. Andrew Mckenzie, Richard Hoskins, Thomas Swift , Colin Grant  and Stephen Rimmer, Applied Materials & Interfaces, 2017 – Polystyrene particles shielded from protein adsorption by encasing them in a branched outer shell of glycerol monomethacrylate.