Molecular Models

Images at the head of the website show molecular models of the functional polymer structures we have been researching. Although a brief description of each structure is contained within further details can be found here of each image for more information:

This image shows a low molecular weight Poly(acrylic acid) polymer  which has very different properties to larger molar mass materials. These polymers were prepared for our landmark soft matter paper.

Header 2This model depicts poly(acrylic acid-co-acenapthylene-co-9-anthryl methyl methacrylate).  These fluorescence labels were chosen due to their overlapping spectral regions making them suitable for FRET experimentation.

Header 1

This model shows vancomycin ligands attached to a branched poly(NIPAM) backbone. Bacteria binding polymers have been a booming topic of research for us with several PhD students and postdocs surging towards this field. Vancomycin functionalised poly(N-isopropylacrylamide) was our first such reported polymer but several more have been reported or are in development.

Header 3

This model shows the surface of a hydrogel formed from glycerol monomethacrylate, ethylene glycol dimethacrylate, lauryl methacrylate and glycidyl methacrylate, which have been post functionalised with 1,4-diaminobutane. In 2014 we reported hydrogels suitable for corneal epithelisation due to their excellent cell-adhesive behaviours.

This model depicts a linear poly(AMPS) molecule as used to prepare core shell particles which released VEGF Growth factors. The linear PAMPS released them much more quickly than the branched polymer indicating it produced more ‘leaky’ particles.

This model depicts a linear an acrylic acid and acrylamide backbone monomers facing in each other. In acidic media they will hydrogen bond along the polymer backbones, causing irreversible (dependent on the pH) aggregation of the polymers.

This model shows multiple trihistidine groups, a pH responsive tripeptide, that have been chemically attached to a branched polymer chain end. Repeated studies of highly branched materials have shown they are extremely responsive to chain end effects, as we proved using the spectroscopic ruler technique in our 2016 paper.