A new paper showcasing our collaborative work with Dr Shepherd in the University of Sheffield has just been published in ChemComm. This work, writing by Joey Shepherd, Tom Swift, Chien-Yi Chang, James R Boyne, Stephen Rimmer and William Martin showcases how HB-PNIPAM-HL can act as a quorum sensing antagonist and modulate how bacterial organisms communicate with one another.
Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.