An advanced proof of our latest paper is available online at an ACS journal Applied Materials and Interfaces. This work, titled ‘Core(polystyrene)-shell(poly(glycerol mono-methacrylate)) particles) can be found here.
A set of water swollen core-shell particles was synthesized by polymerization of a 1,3-dioxolane-functional monomer in water using emulsion polymerization. After removal of the 1,3-dioxolane group the particles’ shells were shown to swell in aqueous media. On hydrolysis the particles increased in size from around 70 nm to 100-130 nm. A bicinchoninic acid assay and zeta potential measurements were used to investigate adsorption of lysozyme, albumin or fibrinogen. Each of the core shell particles adsorbed significantly less protein than the non-coated core, polystyrene particles. There were differences observed as both the amount of a difunctional, crosslinking, monomer and the amount of shell monomer in the feed were changed. The core-shell particles were shown to be resistant to protein adsorption and the degree to which the three proteins adsorbed was dependent on the formulation of the shell.