Controlling angiogenesis by delivery of vascular endothelial growth factor and platelet derived growth factor
An EPSRC funded Doctoral Training Center for Tissue Engineering and Regenerative Medice PhD supervised by Prof Stephen Rimmer, Prof Sheila Mac Neil and Dr Paul Genever [2011-2015]
Angiogenesis is the formation of new blood vessels from a pre-existing vascular network. It plays a vital role in the healing of tissues by establishing a blood supply. This process is stimulated by growth factors, particularly Vascular Endothelial Growth Factor (VEGF) and Platelet Derived Growth Factor (PDGF). These promote endothelial cell proliferation, migration and survival, along with recruitment of pericytes to stabilise and strengthen newly formed blood vessels.
The overall aim of this project is to produce a material capable of releasing both VEGF165 and PDGF-BB with a controlled release profile. This is done using core shell polymer latexes. The charged outer shell of the particles can be swollen allowing growth factors to bind and be released for up to 30 days. This project in joint between University of Sheffield Department of Chemistry, University of Sheffield Kroto Research Institute and University of York Department of Biology.
– Controlled delivery of cytokine growth factors mediated by core-shell particles with poly(acrylamidomethylpropane sulphonate) shells, L. Platt, L. Kelly, S. Rimmer, J. Mater. Chem. B, 2, 494-501 (2014)