Past Members

Ryan Taylor

Scaffolds with controlled mechanical properties for peripheral nerve regeneration

PhD project supervised by Prof. S. Rimmer, Prof. J. Haycock, and Dr. F. Claeyssens and is funded by the EPSRC [2012-2015]

The ‘gold standard’ for neural repair is the autologous graft. This is not without its downsides i.e. donor site morbidity and limited availability of nerves due to the size of the donor nerve having to match the nerve at the site of injury. The aim of the project is to produce a functional nerve guidance conduit which enhances and directs cellular growth, giving an alternative to the autologous graft. A glyceryl methacrylate-statlauryl methacrylate-stat-ethylene glycol dimethacrylate hydrogel is to be synthesised into a tubular structure. This copolymer has poor cell adhesive properties but will be enhanced with the peptide GRGDS (a mimic of fibronectin) to give the conduit cell adhesive properties and IKVAV (a mimic of laminin) to enhance the adhesion and neurite outgrowth.

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