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Binding Bacteria to Highly Branched Poly(N-isopropyl acrylamide) Modified with Vancomycin Induces the Coil-to-Globule Transition

Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition.

A new communication by Joanna Shepherd, Prodip Sarker, Kathryn Swindells, Ian Douglas, Sheila MacNeil, Linda Swanson and Stephen Rimmer has just been published in the Journal of the American Chemical Society.

Abstract:
Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition. The polymers aggregated this Gram-positive bacteria (but not Gram-negative bacteria) over a wide range of temperatures, but cooling to 24−26 °C progressed the polymer-bound bacteria through a globule-to-coil phase transition, after which the bacteria were released.

The full paper can be found here: http://pubs.acs.org/doi/abs/10.1021/ja907466y