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Dr Sally Hopkins

The Development of Nanoparticles for Cell Protection

PhD project supervised by Professor Sheila MacNeil and Dr Steve Rimmer, funded by EPSRC and the White Rose Doctoral Training Centre at the Lifescience Interface. [2005-2008]

Description

Stimuli responsive polymers have been synthesised and the formulation tuned in order to form sub-micron particles when the temperature is above the lower critical solution temperature (LCST). The highly branched NIPAM polymers are not stabilised by a surfactant system, all stabilisation is due to the hyper branched poly(NIPAM) architecture of the globules above the LCST. The polymers are to encapsulate protective agents and then be internalised by cells.
Polymer chains swell on heating , then aggregate.

Diagram to show the effect of temperature change on highly branched poly(NIPAM)s

Above: Diagram to show the effect of temperature change on highly branched poly(NIPAM)s